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A recovering addict probably said it best, and I’m paraphrasing here: “We get high because it makes us feel better than when we are not.”  This is why many of us have succumbed at some time or another to the siren call for mood-boosting substances....

All creatures naturally seek pleasure and avoid pain. People (and animals) often crave something more--to feel high. For millions of years, humans have used alcohol and other drugs, elephants have sought out fermented fruit, and cats have rolled ecstatically in catnip. But we have also...